Ipriflavone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

伊普黄酮（7-异丙氧基异黄酮）用于抑制骨吸收。

Ipriflavone (7-Isopropoxyisoflavon) is used to inhibit bone resorption.(In Vitro):Ipriflavone inhibits the proliferation and DNA synthesis of MDA-231 cells and blocks the ligand-induced phosphorylation of Tyr(845) of the EGFR. Ipriflavone does not promote apoptosis of MDA-231 cells. Ipriflavone also promotes the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like cells as well as the activity of alkaline phosphatase. (In Vivo):Daily oral administration of ipriflavone at 12 mg/mouse significantly inhibits the development of new osteolytic bone metastases and the progression of established osteolytic lesions, prolonging the life of tumor-bearing mice. Ipriflavone reduces the number of osteoclasts at the bone-cancer interface with no severe adverse effects on the host. 1-month treatment with ipriflavone increases bone density and improves the biomechanical properties of adult rat male bones without altering mineral composition.

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Osteofix

Others

Other Targets

advanced glycation end products

Other Indications

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35212-22-7

280.32

C18H16O3

>98% (HPLC)

Ethanol: 2 mg/mL (7.13 mM); DMSO: 56 mg/mL (199.77 mM)

O=C1C(C2=CC=CC=C2)=COC3=CC(OC(C)C)=CC=C13

7-isopropoxy-3-phenyl-4H-chromen-4-one

(-20℃)

With Ice Pack

≥ 2 years